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Dent @ Home with Brian Brown

June 4 @ 11:00 am - 12:00 pm PDT

COVID Vaccines and the Future of Hacking our Immune System to Fight Disease

Thanks to vaccines built from Messenger RNA (mRNA), 132 Million Americans are now fully vaccinated against SARS-CoV-2. Vaccine researchers believe the success of these inoculations will usher in the most dramatic change to vaccine creation since cow viruses were first used two centuries ago.

While most view the use of RNA to build the body’s immunity against diseases as a late-breaking approach, for more than 25 years laboratories across the globe have been exploring the use of RNA and other gene engineering technologies, to direct the body’s immune system against diseases.

One of the scientists who has been helping lead this effort is Dr. Brian Brown. Dr. Brown is the Associate Director of the Precision Immunology Institute (PrIISM), Director of the Icahn Genomics Institute, and a Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. His lab researches a broad area of investigation that spans immune oncology, molecular immunology, microRNA biology, and genetic engineering.

In this Dent @ Home talk, Dr. Brown will discuss how mRNA technology emerged as the leading basis for new vaccines, including for COVID, and how other next generation technologies are being developed to ‘hack’ the immune system and treat a broad range of diseases. He will also delve into the promise of his research into creating treatments for cancer and other diseases.

Dr. Brian Brown is an immunologist and molecular biologist whose research has a strong focus on biotechnology and therapeutics. His training began with his doctoral studies in Canada and his work to establish ways to overcome the immune response hindering gene therapy. He subsequently did his postdoctoral studies in Italy where he helped develop a new platform for controlling gene expression, which has led to improvements in experimental treatments for genetic disease, cancer, and viral infection. Dr. Brown’s lab is now working to identify the factors that control immunity and tolerance, and translate these findings in to strategies that can be used to turn the immune system against cancer or viruses. In 2008 Dr. Brown joined the faculty of Mount Sinai he was promoted to full Professor with tenure in 2018. In 2016 he became the Associate Director of Mount Sinai’s Precision Immunology Institute (PrIISM) and in 2021 he was named acting Director of the Icahn Genomics Institute.

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June 4
11:00 am - 12:00 pm PDT